For Healthcare Professionals Outside the US
Tafinlar + Mekinist is indicated for adjuvant treatment of adult patients with Stage III melanoma with a BRAF V600 mutation, following complete resection; for first-line treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation; for adult patients with advanced non-small cell lung cancer (NSCLC) with a BRAF V600 mutation.

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Home > Efficacy > Metastatic BRAF V600+ Melanoma > Progression free survival
For first-line targeted therapy in patients with BRAF V600 positive metastatic melanoma

Extended progression-free survival with TAFINLAR + MEKINIST 

Across COMBI-d and COMBI-v, nearly 1 in 5 patients in the intent-to-treat population were progression free at 5 years (n=563)1

pooled-pfs-5-year-itt-population-desktop-2x


In the pooled analysis, nearly one-third of patients with low tumour burden were progression free at 5 years1* (n=216)

pooled-pfs-5-year-ltb-desktop-2x_0
LDH, lactate dehydrogenase; PFS, progression-free survival.
*Low tumor burden is defined as normal LDH and <3 metastatic sites.
Reference: 1. Robert C, Grob JJ, Stroyakovskiy D, et al. Five-year outcomes with dabrafenib plus trametinib in metastatic melanoma. N Engl J Med. 2019;381(1):626-636.

COVID-19 Update


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During this time of uncertainty it is important to communicate with your patients about COVID-19 to clarify that they should not stop their treatments except under the direction of the treating physician, and to ensure that patients have sufficient drug to avoid any treatment interruptions.

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04/20  G-ONC-1230566

COMBI-AD was a double-blind, placebo-controlled, Phase 3 trial that compared Tafinlar + Mekinist vs placebo4

ELIGIBILITY REQUIREMENTS

  • Resection of histologically confirmed Stage IIIA, B, or C with BRAF V600E or BRAF V600K mutation
  • ECOG performance status ≤1
  • No prior systemic anticancer treatment or radiotherapy for melanoma
TAFINLAR 150 mg BID + MEKINIST
2 mg QD (n=438)
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Placebo (n=432)

STUDY ENDPOINTS

  • Primary endpoint was RFS
  • Secondary endpoints were OS, distant metastasis-free survival, freedom from relapse, and safety
COMBI-d phase 3 study: Tafinlar® (dabrafenib) + Mekinist® (trametinib) vs Tafinlar® monotherapy