For Healthcare Professionals Outside the US
Tafinlar + Mekinist is indicated for adjuvant treatment of adult patients with Stage III melanoma with a BRAF V600 mutation, following complete resection; for first-line treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation; for adult patients with advanced non-small cell lung cancer (NSCLC) with a BRAF V600 mutation.

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Home > Efficacy > BRAF V600+ NSCLC > Disease Control Rate

An effective, targeted combination that provides demonstrated results

Treatment-naïve patients with BRAF V600+ NSCLC: Maximum reduction in target lesions (investigator assessed)1

TAFINLAR® (dabrafenib) + MEKINIST® (trametinib) efficacy in treatment-naïve patient

Previously treated patients with BRAF V600+ NSCLC: Maximum reduction in target lesions (investigator-assessed)1

TAFINLAR® (dabrafenib) and MEKINIST® (trametinib) efficacy in previously treated patients
DCR=CR + PR + SD.
CR, complete response; DCR, disease control rate; NE, not evaluable; PD, progressive disease; PR, partial response; SD, stable disease.
Reference: 1. Data on file (Planchard manuscript); Novartis Pharmaceuticals Corp; 2020. 

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04/20  G-ONC-1230566

COMBI-AD was a double-blind, placebo-controlled, Phase 3 trial that compared Tafinlar + Mekinist vs placebo4

ELIGIBILITY REQUIREMENTS

  • Resection of histologically confirmed Stage IIIA, B, or C with BRAF V600E or BRAF V600K mutation
  • ECOG performance status ≤1
  • No prior systemic anticancer treatment or radiotherapy for melanoma
TAFINLAR 150 mg BID + MEKINIST
2 mg QD (n=438)
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Placebo (n=432)

STUDY ENDPOINTS

  • Primary endpoint was RFS
  • Secondary endpoints were OS, distant metastasis-free survival, freedom from relapse, and safety
COMBI-d phase 3 study: Tafinlar® (dabrafenib) + Mekinist® (trametinib) vs Tafinlar® monotherapy